列线图
医学
无线电技术
前列腺癌
磁共振成像
放射科
前列腺
癌症
肿瘤科
内科学
作者
Are Losnegård,Lars A. R. Reisæter,Ole J. Halvorsen,Jakub Jurek,Jörg Aßmus,Jarle B. Arnes,Alfred Honoré,Jan Ankar Monssen,Erling Andersen,Ingfrid S. Haldorsen,Arvid Lundervold,Christian Beisland
标识
DOI:10.1177/0284185120905066
摘要
Background To investigate whether magnetic resonance (MR) radiomic features combined with machine learning may aid in predicting extraprostatic extension (EPE) in high- and non-favorable intermediate-risk patients with prostate cancer. Purpose To investigate the diagnostic performance of radiomics to detect EPE. Material and Methods MR radiomic features were extracted from 228 patients, of whom 86 were diagnosed with EPE, using prostate and lesion segmentations. Prediction models were built using Random Forest. Further, EPE was also predicted using a clinical nomogram and routine radiological interpretation and diagnostic performance was assessed for individual and combined models. Results The MR radiomic model with features extracted from the manually delineated lesions performed best among the radiomic models with an area under the curve (AUC) of 0.74. Radiology interpretation yielded an AUC of 0.75 and the clinical nomogram (MSKCC) an AUC of 0.67. A combination of the three prediction models gave the highest AUC of 0.79. Conclusion Radiomic analysis combined with radiology interpretation aid the MSKCC nomogram in predicting EPE in high- and non-favorable intermediate-risk patients.
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