[Algorithmic analysis of potential drug-drug interactions using direct-acting antiviral agents and concomitant medications in chronic hepatitis C].

Direct acting antiviral agents (DAAs) metabolism and pharmacokinetics of concomitant medications data were extracted and analyzed from the database of Chinese Health Insurance between 2013 and 2015. A potential drug-drug interactions (DDI) were calculated by integration of extracted data and confirmed by using Liverpool website (https: //www.hep-druginteractions.org/). A new algorithm is suggested for management of DDI between DAAs and concomitant medications.根据中国城镇医保数据库分析慢性丙型肝炎常见合并疾病和合并疾病的常用药物，分析丙型肝炎直接抗病毒药物（DAAs）的代谢途径，推测不同药物潜在的药物相互作用，并根据利物浦大学丙型肝炎药物相互作用网站验证，提出了慢性丙型肝炎合并其他疾病时，DAAs选择和其他药物选择的建议流程。.