核酸
淀粉样蛋白(真菌学)
疾病
蛋白质聚集
淀粉样纤维
功能(生物学)
癌症
内在无序蛋白质
化学
生物
突变体
细胞生物学
淀粉样β
生物化学
医学
遗传学
病理
基因
无机化学
作者
Guilherme A. P. de Oliveira,Yraima Cordeiro,Jerson L. Silva,Tuane C. R. G. Vieira
出处
期刊:Advances in protein chemistry and structural biology
日期:2019-01-01
卷期号:: 289-331
被引量:55
标识
DOI:10.1016/bs.apcsb.2019.08.002
摘要
Liquid-liquid phase separation (LLPS) and phase transition (LLPT) of proteins and nucleic acids have emerged as a new paradigm in cell biology. Here we will describe the recent findings about LLPS and LLPT, including the molecular and physical determinants leading to their formation, the resulting functions and their implications in cell physiology and disease. Amyloid aggregation is implicated in many neurodegenerative diseases and cancer, and LLPS of proteins involved in these diseases appear to be related to their function in different cell contexts. Amyloid formation would correspond to an irreversible liquid-to-solid transition, as clearly observed in the case of PrP, TDP43, FUS/TLS and tau protein in neurodegenerative pathologies as well as with the mutant tumor suppressor p53 in cancer. Nucleic acids play a modulatory effect on both LLPS and amyloid aggregation. Understanding the molecular events regulating how the demixing process advances to solid-like fibril materials is crucial for the development of novel therapeutic strategies against cancer and neurodegenerative maladies.
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