A New Approach to Osmium-Catalyzed Asymmetric Dihydroxylation and Aminohydroxylation of Olefins

Simple hydroxyamino acid derivatives act as chiral ligands in osmium-catalyzed dihydroxylation and aminohydroxylation of olefins (see scheme). These are the first examples of asymmetric osmium-catalyzed processes proceeding in the second catalytic cycle with resident ligands on the metal center.