化学
雄激素受体
立体化学
抗雄激素
侧链
化学合成
配体(生物化学)
雄激素
衍生工具(金融)
受体
前列腺癌
生物化学
体外
有机化学
激素
内科学
医学
癌症
经济
金融经济学
聚合物
作者
Marcian E. Van Dort,Y Jung
标识
DOI:10.1016/s0960-894x(01)00146-9
摘要
A series of arylhydantoin derivatives modeled after the antiandrogen RU 58841 was generated to identify potential candidates for development as androgen receptor (AR) radioligands. Side-chain modified derivatives of RU 58841, suitable for labeling with either carbon-11 or radiohalogens (fluorine-18, iodine-123), were synthesized and tested for their AR binding affinities. The N-(iodopropenyl) derivative 13 (Ki = 13 nM) is a potential candidate for development as a radioiodinated AR ligand.
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