The Neural Correlates of Anhedonia in Major Depressive Disorder

无血性 心理学 功能磁共振成像 重性抑郁障碍 神经科学 焦虑 心情 前额叶腹内侧皮质 抗抑郁药 前额叶皮质 愉快 意识的神经相关物 临床心理学 发展心理学 认知心理学 认知 精神科
作者
Paul Keedwell,Chris Andrew,Steven Williams,Mick Brammer,Mary L. Phillips
出处
期刊:Biological Psychiatry [Elsevier BV]
卷期号:58 (11): 843-853 被引量:635
标识
DOI:10.1016/j.biopsych.2005.05.019
摘要

Background

Anhedonia is a relative lack of pleasure in response to formerly rewarding stimuli. It is an important diagnostic feature of major depressive disorder (MDD), and predicts antidepressant efficacy. Understanding its neurobiological basis may help to target new treatments and predict treatment outcomes. Using a novel paradigm, we aimed to explore the correlations between anhedonia severity and magnitude of neural responses to happy and sad stimuli in regions previously implicated in studies of human reward processing and depressive anhedonia.

Methods

Neural responses to happy and sad emotional stimuli (autobiographical prompts and mood congruent facial expressions) were measured using blood oxygen level dependent (BOLD) functional magnetic resonance imaging in twelve MDD individuals with varying degrees of anhedonia.

Results

In response to happy stimuli, anhedonia, but not depression severity per se, was positively and negatively correlated with ventromedial prefrontal cortex (VMPFC) and amygdala/ventral striatal activity, respectively. State anxiety independently contributed to a VMPFC-subcortical dissociation of response to happy (but not sad) stimuli, which was similar, but different, to anhedonia.

Conclusions

These findings suggest that anhedonia and state anxiety are associated with dysfunction within neural systems underlying the response to, and assessment of, the rewarding potential of emotive stimuli in MDD, and highlight the importance of employing a symptom-dimension-based approach in the examination of the neurobiology of depression.
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