聚乙烯吡咯烷酮
苯巴比妥
无定形固体
脯氨酸
化学
Crystal(编程语言)
生物化学
结晶学
有机化学
药理学
医学
计算机科学
氨基酸
程序设计语言
作者
Ossi Korhonen,Chandan Bhugra,Michael J. Pikal
摘要
Abstract
The aim of the present study is to determine if the correlation between molecular mobility and crystallization growth rates exists over a broad temperature range from temperatures below the glass transition (Tg) to temperatures above the glass transition. Phenobarbital and solid dispersions of phenobarbital with PVP and L‐proline were studied in this research. Relaxation times below and above the Tg were measured. Crystallization was followed in a hot‐stage microscope and crystal growth rates were measured by observing radial growth of a single crystal. Arrhenius type temperature dependences were found both in relaxation times and crystal growth rates over studied temperature ranges, in all cases studied except in the case of pure phenobarbital, where a change of slope was observed for the crystal growth rate for the temperature range below Tg. For all cases, molecular mobility was correlated with crystal growth rate, for the temperature range studied, with a coupling coefficient of 0.38 for phenobarbital, and 0.23 and 0.28 for solid dispersions with PVP and proline respectively. By establishing the coupling between molecular mobility and crystal growth rate, predictive models can be created to estimate the stability of amorphous materials both, for pure form as well as for solid dispersions.
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