中国仓鼠
生物
中期
染色体
分子生物学
染色
神经母细胞瘤
核型
仓鼠
细胞培养
体外
细胞
表型
细胞生物学
遗传学
基因
作者
June L. Biedler,Barbara A. Spengler
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1976-01-16
卷期号:191 (4223): 185-187
被引量:383
标识
DOI:10.1126/science.942798
摘要
Large, homogeneously staining chromosome regions which lack the longitudinal differentiation ordinarily revealed by cytogenetic "banding" methods have been found in antifolate-resistant Chinese hamster cells and also in human neuroblastoma cells established in vitro. The drug-resistant cells are characterized by excessive production of the target enzyme, dihydrofolate reducatase, while the human neuroblastoma cells have phenotypes of normal neuronal cells. The homogeneously staining region appears to represent a novel metaphase chromosome anaomaly which may have functional significance in cells with specialized properties.
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