生物
CpG站点
DNA甲基化
甲基化
发起人
亚硫酸氢盐测序
癌症研究
分子生物学
癌症
淋巴瘤
基因
表观遗传学
B细胞淋巴瘤
亚硫酸氢盐
遗传学
免疫学
基因表达
作者
Jingyu Deng,Han Liang,Qiuping Dong,Yachao Hou,Xingming Xie,Jun Yu,Daiming Fan,Xishan Hao
出处
期刊:Open Biology
[The Royal Society]
日期:2014-07-01
卷期号:4 (7): 140067-140067
被引量:13
摘要
The methylation of B-cell CLL/lymphoma 6 member B (BCL6B) DNA promoter was detected in several malignancies. Here, we quantitatively detect the methylated status of CpG sites of BCL6B DNA promoter of 459 patients with gastric cancer (GC) by using bisulfite gene sequencing. We show that patients with three or more methylated CpG sites in the BCL6B promoter were significantly associated with poor survival. Furthermore, by using the Akaike information criterion value calculation, we show that the methylated count of BCL6B promoter was identified to be the optimal prognostic predictor of GC patients.
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