医学
溃疡指数
有丝分裂指数
内科学
伤口愈合
胃肠病学
米索前列醇
胃粘膜
免疫组织化学
再生(生物学)
有丝分裂
细胞生长
胃
病理
外科
生物
怀孕
遗传学
流产
细胞生物学
作者
S Levi,Robert A. Goodlad,C Y Lee,G. Stamp,Mark Walport,Nicholas A. Wright,H J Hodgson
出处
期刊:The Lancet
[Elsevier]
日期:1990-10-01
卷期号:336 (8719): 840-843
被引量:182
标识
DOI:10.1016/0140-6736(90)92341-e
摘要
To find out whether non-steroidial anti-inflammatory drugs (NSAIDs) inhibit the proliferation of mucosal cells that normally leads to healing of gastric ulcers a microdissection technique was used to quantify mitosis in gastric glands at the ulcer edge in relation to that in the adjacent mucosa. The regeneration index thus obtained of the ulcer edge was greater in the 9 subjects with gastric ulcers not taking NSAIDs (mean index 3·1 [SEM 0·61]) than that in the 8 patients taking NSAIDs (index 1·49 [0·16]). In rats in which gastric ulcers were produced with a cryoprobe, the ulcers were larger and slower to heal in those receiving indomethacin than in controls; also, immunohistochemical staining indicated significantly fewer mitotic cells in glands adjacent to the ulcer in indomethacin-treated rats (8 mitoses [SEM 3]) than in control animals (25 [5]). The prostaglandin E1 analogue misoprostol reversed the inhibition of healing and substantially restored the proliferative rate in the animals. Inhibition of epithelial cell division normally involved in gastric ulcer healing would contribute to the high prevalence of gastric ulcer during NSAID therapy.
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