炎症
肝星状细胞
纤维化
TLR4型
肝纤维化
受体
Toll样受体
医学
免疫学
伤口愈合
病理
先天免疫系统
内科学
作者
Jean‐Philippe Pradère,Juliane S. Troeger,Dianne H. Dapito,Ali Mencin,Robert F. Schwabe
出处
期刊:Seminars in Liver Disease
[Georg Thieme Verlag KG]
日期:2010-07-21
卷期号:30 (03): 232-244
被引量:144
标识
DOI:10.1055/s-0030-1255353
摘要
Inflammation is strongly associated with chronic hepatic injury and the ensuing wound-healing process. Recent evidence from mouse models and human studies implicates Toll-like receptors (TLRs) as important regulators of the inflammatory response and a functional link between inflammation and fibrosis in the chronically injured liver. Here, we review mechanisms by which TLR4 and TLR4 ligands from the intestinal microbiota contribute to hepatic injury, inflammation, hepatic stellate cell activation, and fibrosis.
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