亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Application of Pediatric and Adult Guidelines for Treatment of Lipid Levels Among US Adolescents Transitioning to Young Adulthood

医学 全国健康与营养检查调查 指南 年轻人 人口 老年学 儿科 环境卫生 病理
作者
Holly C. Gooding,Angie Mae Rodday,John B. Wong,Matthew W. Gillman,Donald M. Lloyd‐Jones,Laurel K. Leslie,Sarah D. de Ferranti
出处
期刊:JAMA Pediatrics [American Medical Association]
卷期号:169 (6): 569-569 被引量:40
标识
DOI:10.1001/jamapediatrics.2015.0168
摘要

Importance

Health care practitioners who care for adolescents transitioning to adulthood often face incongruent recommendations from pediatric and adult guidelines for treatment of lipid levels.

Objective

To compare the proportion of young people aged 17 to 21 years who meet criteria for pharmacologic treatment of elevated low-density lipoprotein cholesterol (LDL-C) levels under pediatric vs adult guidelines.

Design, Setting, and Participants

We performed a cross-sectional analysis of the National Health and Nutrition Examination Survey (NHANES) population. Surveys were administered from January 1, 1999, through December 31, 2012, and the analysis was performed from June through December 2014. Participants included 6338 individuals aged 17 to 21 years in the United States.

Main Outcomes and Measures

To estimate the number and proportion of individuals aged 17 to 21 years in the NHANES population who were eligible for statin therapy, we applied treatment algorithms from the 2011 Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents of the National Heart, Lung, and Blood Institute and the 2013 Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults from the American College of Cardiology and American Heart Association. After imputing missing data and applying NHANES sampling weights, we extrapolated the results to 20.4 million noninstitutionalized young people aged 17 to 21 years living in the United States.

Results

Of the 6338 young people aged 17 to 21 years in the NHANES population, 2.5% (95% CI, 1.8%-3.2%) would qualify for statin treatment under the pediatric guidelines compared with 0.4% (95% CI, 0.1%-0.8%) under the adult guidelines. Participants who met pediatric criteria had lower mean (SD) LDL-C levels (167.3 [3.8] vs 210.0 [7.1] mg/dL) but higher proportions of other cardiovascular risk factors, including hypertension (10.8% vs 8.4%), smoking (55.0% vs 23.9%), and obesity (67.7% vs 18.2%) compared with those who met the adult guidelines. Extrapolating to the US population of individuals aged 17 to 21 years represented by the NHANES sample, 483 500 (95% CI, 482 100-484 800) young people would be eligible for treatment of LDL-C levels if the pediatric guidelines were applied compared with only 78 200 (95% CI, 77 600-78 700) if the adult guidelines were applied.

Conclusions and Relevance

Application of pediatric vs adult guidelines for lipid levels, which consider additional cardiovascular risk factors beyond age and LDL-C concentration, might result in statin treatment for more than 400 000 additional adolescents and young adults.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
3秒前
量子星尘发布了新的文献求助10
10秒前
顺心蜜粉应助紧张的书本采纳,获得10
44秒前
今后应助echo采纳,获得10
44秒前
立夏完成签到,获得积分10
1分钟前
量子星尘发布了新的文献求助10
1分钟前
lixuebin完成签到 ,获得积分10
2分钟前
gavin完成签到 ,获得积分10
2分钟前
腐竹完成签到,获得积分10
2分钟前
2分钟前
大气建辉完成签到 ,获得积分10
3分钟前
量子星尘发布了新的文献求助10
3分钟前
3分钟前
3分钟前
5分钟前
杪夏二八完成签到 ,获得积分10
5分钟前
量子星尘发布了新的文献求助10
5分钟前
5分钟前
科研通AI2S应助科研通管家采纳,获得10
5分钟前
义气雁完成签到 ,获得积分10
5分钟前
wodetaiyangLLL完成签到 ,获得积分10
5分钟前
5分钟前
6分钟前
6分钟前
Ava应助飞翔的企鹅采纳,获得10
6分钟前
6分钟前
量子星尘发布了新的文献求助10
6分钟前
6分钟前
noob_发布了新的文献求助20
6分钟前
6分钟前
6分钟前
noob_完成签到,获得积分20
6分钟前
echo发布了新的文献求助10
6分钟前
founder发布了新的文献求助20
7分钟前
7分钟前
飞翔的企鹅完成签到,获得积分10
7分钟前
7分钟前
MchemG应助科研通管家采纳,获得10
7分钟前
MchemG应助科研通管家采纳,获得10
7分钟前
量子星尘发布了新的文献求助10
8分钟前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3976665
求助须知:如何正确求助?哪些是违规求助? 3520770
关于积分的说明 11204801
捐赠科研通 3257528
什么是DOI,文献DOI怎么找? 1798733
邀请新用户注册赠送积分活动 877897
科研通“疑难数据库(出版商)”最低求助积分说明 806629