作者
Reina N. Fuji,Michael Flagella,Miriam Baca,Marco A. S. Baptista,Jens Brodbeck,Bryan Chan,Brian Fiske,Lee Honigberg,Adrian M. Jubb,Paula Katavolos,Donna W. Lee,Sock-Cheng Lewin-Koh,Tori Lin,Xingrong Liu,Shannon Liu,Joseph P. Lyssikatos,Jennifer O’Mahony,Mike Reichelt,Merone Roose‐Girma,Zejuan Sheng,Todd Sherer,Ashley Smith,Margaret Solon,Zachary K. Sweeney,Jacqueline M. Tarrant,Alison Urkowitz,Søren Warming,Murat Yaylaoglu,Shuo Zhang,Haitao Zhu,Anthony A. Estrada,Ryan J. Watts
摘要
LRRK2 kinase inhibitors, under development for Parkinson’s disease, have an effect on type II pneumocytes in nonhuman primate lung, suggesting that pulmonary toxicity may be a critical safety liability.