A Comparison of Serum and Sputum Inflammatory Mediator Profiles in Patients with Asthma and COPD

慢性阻塞性肺病 医学 哮喘 免疫学 炎症 嗜酸性粒细胞增多症 细胞因子 促炎细胞因子 嗜酸性 抗体 内科学 病理 肺结核
作者
Yuxue Cao,Weiyi Gong,H Zhang,Bolun Liu,B Li,Xiao Wu,Xiaohong Duan,Jingcheng Dong
出处
期刊:Journal of International Medical Research [SAGE]
卷期号:40 (6): 2231-2242 被引量:12
标识
DOI:10.1177/030006051204000621
摘要

Objective: To investigate serum and sputum cytokine profiles in asthma and chronic obstructive pulmonary disorder (COPD). Methods: Clinical characteristics, blood and sputum samples were collected from asthma (n = 37) and COPD (n = 36) patients, and healthy subjects (n = 39). Cytokines were measured by enzyme-linked immunosorbent assay (ELISA) and inflammation antibody array; levels were analysed according to smoking status and presence of eosinophilia in the airways of COPD/asthma patients, and compared with those in healthy subjects. Results: ELISA revealed a significant difference in the expression of only a few cytokines in the COPD versus asthma groups, and in both patient groups compared with healthy subjects. The antibody array showed greater differentiation in inflammatory mediators. In the subphenotype analysis, the differential expression of cytokines was more significant between eosinophilic and noneosinophilic airway inflammation than between asthma and COPD, according to both the ELISA and antibody array. There was little difference in cytokine expression between smoking and nonsmoking subgroups. Conclusions: Differential expression of inflammatory mediators is present between patients with COPD or asthma, and eosinophilic or noneosinophilic airway inflammation, and contributes to understanding the cytokine network of airway inflammation.

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