卵黄囊
病理
髓腔
腺癌
肠化生
化生
胎儿
组织发生
医学
上皮
生物
免疫组织化学
内科学
癌症
胚胎
发育不良
怀孕
细胞生物学
遗传学
作者
Teiichi Motoyama,Kikuo Aizawa,Hidenobu Watanabe,Masayuki Fukase,Kiyoko Saito
标识
DOI:10.1111/j.1440-1827.1993.tb02549.x
摘要
Nine cases of gastric carcinoma with excessive production of alpha-fetoprotein (AFP) were analyzed morphologically, histochemically and biochemically. Consequently, it was proposed that AFP-producing gastric carcinomas should be divided into three subtypes: (i) hepatoid type; (ii) yolk sac tumor-like type; and (iii) fetal gastrointestinal type. The data from the study suggested that the hepatoid type and the yolk sac tumor-like type are derived from liver cell metaplasia and yolk sac cell metaplasia of common poorly differentiated medullary adenocarcinoma, respectively. The fetal gastrointestinal type seemed to be a result of the imitation of fetal gastrointestinal epithelium by common tubular adenocarcinoma. The hepatoid type was also the most common in the file of AFP-producing gastric carcinoma. Unfortunately, most of the hepatoid types seemed to be highly malignant.
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