干细胞
细胞生物学
生物
利基
细胞分化
平衡
干细胞巢
成体干细胞
祖细胞
遗传学
基因
生态学
作者
Kateri Moore,Ihor R. Lemischka
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2006-03-31
卷期号:311 (5769): 1880-1885
被引量:1445
标识
DOI:10.1126/science.1110542
摘要
A constellation of intrinsic and extrinsic cellular mechanisms regulates the balance of self-renewal and differentiation in all stem cells. Stem cells, their progeny, and elements of their microenvironment make up an anatomical structure that coordinates normal homeostatic production of functional mature cells. Here we discuss the stem cell niche concept, highlight recent progress, and identify important unanswered questions. We focus on three mammalian stem cell systems where large numbers of mature cells must be continuously produced throughout adult life: intestinal epithelium, epidermal structures, and bone marrow.
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