Safety of ovarian preservation in women with stage I and II cervical adenocarcinoma: a retrospective study and meta-analysis

医学 阶段(地层学) 宫颈癌 回顾性队列研究 肿瘤科 转移 卵巢切除术 妇科 淋巴结 淋巴结切除术 子宫切除术 内科学 外科 癌症 古生物学 生物
作者
Jing Chen,Rui Wang,Bo Zhang,Xingguang Lin,Juncheng Wei,Yulin Jia,Yongqi Yin,Shuangmei Ye,Tao Zhu,Gang Chen,Yongxun Yuan,Weiguo Lü,Ke-Zhen Li
出处
期刊:American Journal of Obstetrics and Gynecology [Elsevier BV]
卷期号:215 (4): 460.e1-460.e13 被引量:30
标识
DOI:10.1016/j.ajog.2016.04.023
摘要

Background The safety of ovarian preservation remains uncertain in women with cervical adenocarcinoma and significant risk factors for ovarian metastases vary among different studies. Objective We sought to evaluate the impact of ovarian preservation on prognosis in women with cervical adenocarcinoma and to assess clinical factors associated with ovarian metastases. Study Design A retrospective study of 194 women with cervical adenocarcinoma was conducted and 159 women were followed up until the end of the study. To compare the impact of ovarian preservation on prognosis, women with successful follow-up were studied, including 33 women with ovarian preservation and 126 women who underwent bilateral salpingo-oophorectomy. For women who underwent radical hysterectomy, pelvic lymphadenectomy, and bilateral salpingo-oophorectomy, the risk factors for ovarian metastases were identified. A meta-analysis of the literature was carried out to further validate the findings. Results There was no significant difference in survival between women with bilateral salpingo-oophorectomy and ovarian preservation (P = .423 for disease-free survival; P = .330 for overall survival). Tumor size (>4 cm), deep cervical stromal invasion, and lymph node metastasis were significant independent prognostic factors related to poor disease-free survival, and lymph node metastasis was significantly associated with overall survival. Of 153 women with cervical adenocarcinoma who underwent bilateral salpingo-oophorectomy, a significant difference was found in the relationship between ovarian metastasis and deep cervical stromal invasion, lymph node metastasis, and parametrial invasion. The meta-analysis showed that clinical stage IIB vs I-IIA (odds ratio, 4.64; 95% confidence interval, 2.11–10.23), deep stromal invasion (odds ratio, 10.63; 95% confidence interval, 3.12–36.02), lymph node metastasis (odds ratio, 8.54; 95% confidence interval, 4.15–17.57), corpus uteri invasion (odds ratio, 7.39; 95% confidence interval, 3.69–14.78), and parametrial invasion (odds ratio, 9.72; 95% confidence interval, 4.67–20.22) were significantly related to ovarian metastasis. Conclusion Ovarian preservation has no effect on prognosis in women with early-stage cervical adenocarcinoma. Risk factors for ovarian metastases were stage IIB, deep cervical stromal invasion, lymph node metastasis, corpus uteri invasion, and parametrial invasion. In women with early-stage cervical adenocarcinoma without these risk factors, ovarian conservation can be considered. The safety of ovarian preservation remains uncertain in women with cervical adenocarcinoma and significant risk factors for ovarian metastases vary among different studies. We sought to evaluate the impact of ovarian preservation on prognosis in women with cervical adenocarcinoma and to assess clinical factors associated with ovarian metastases. A retrospective study of 194 women with cervical adenocarcinoma was conducted and 159 women were followed up until the end of the study. To compare the impact of ovarian preservation on prognosis, women with successful follow-up were studied, including 33 women with ovarian preservation and 126 women who underwent bilateral salpingo-oophorectomy. For women who underwent radical hysterectomy, pelvic lymphadenectomy, and bilateral salpingo-oophorectomy, the risk factors for ovarian metastases were identified. A meta-analysis of the literature was carried out to further validate the findings. There was no significant difference in survival between women with bilateral salpingo-oophorectomy and ovarian preservation (P = .423 for disease-free survival; P = .330 for overall survival). Tumor size (>4 cm), deep cervical stromal invasion, and lymph node metastasis were significant independent prognostic factors related to poor disease-free survival, and lymph node metastasis was significantly associated with overall survival. Of 153 women with cervical adenocarcinoma who underwent bilateral salpingo-oophorectomy, a significant difference was found in the relationship between ovarian metastasis and deep cervical stromal invasion, lymph node metastasis, and parametrial invasion. The meta-analysis showed that clinical stage IIB vs I-IIA (odds ratio, 4.64; 95% confidence interval, 2.11–10.23), deep stromal invasion (odds ratio, 10.63; 95% confidence interval, 3.12–36.02), lymph node metastasis (odds ratio, 8.54; 95% confidence interval, 4.15–17.57), corpus uteri invasion (odds ratio, 7.39; 95% confidence interval, 3.69–14.78), and parametrial invasion (odds ratio, 9.72; 95% confidence interval, 4.67–20.22) were significantly related to ovarian metastasis. Ovarian preservation has no effect on prognosis in women with early-stage cervical adenocarcinoma. Risk factors for ovarian metastases were stage IIB, deep cervical stromal invasion, lymph node metastasis, corpus uteri invasion, and parametrial invasion. In women with early-stage cervical adenocarcinoma without these risk factors, ovarian conservation can be considered.
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