亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Can Stereotactic Body Radiation Therapy Be a Viable and Efficient Therapeutic Option for Unresectable Locally Advanced Pancreatic Adenocarcinoma? Results of a Phase 2 Study

医学 放射治疗 胰腺癌 多元分析 放射外科 临床终点 单变量分析 无进展生存期 养生 肿瘤进展 内科学 癌症 肿瘤科 外科 放射科 化疗 随机对照试验
作者
Tiziana Comito,Luca Cozzi,Elena Clerici,Ciro Franzese,A. Tozzi,C. Iftode,Pierina Navarria,Giuseppe Roberto D’Agostino,Lorenza Rimassa,Carlo Carnaghi,Nicola Personeni,Maria Chiara Tronconi,Fiorenza De Rose,Davide Franceschini,A.M. Ascolese,Antonella Fogliata,Stefano Tomatis,Armando Santoro,Alessandro Zerbi,Marta Scorsetti
出处
期刊:Technology in Cancer Research & Treatment [SAGE Publishing]
卷期号:16 (3): 295-301 被引量:82
标识
DOI:10.1177/1533034616650778
摘要

Purpose: To assess the efficacy of stereotactic body radiotherapy in patients with unresectable locally advanced pancreatic cancer. Materials and Methods: All patients received a prescription dose of 45 Gy in 6 fractions. Primary end point was freedom from local progression. Secondary end points were overall survival, progression-free survival, and toxicity. Actuarial survival analysis and univariate or multivariate analysis were investigated. Results: Forty-five patients were enrolled in a phase 2 trial. Median follow-up was 13.5 months. Freedom from local progression was 90% at 2 years. On univariate ( P < .03) and multivariate analyses ( P < .001), lesion size was statistically significant for freedom from local progression. Median progression-free survival and overall survival were 8 and 13 months, respectively. On multivariate analysis, tumor size ( P < .001) and freedom from local progression ( P < .002) were significantly correlated with overall survival. Thirty-two (71%) patients with locally advanced pancreatic cancer received chemotherapy before stereotactic body radiotherapy. Median overall survival from diagnosis was 19 months. Multivariate analysis showed that freedom from local progression ( P < .035), tumor diameter ( P < .002), and computed tomography before stereotactic body radiotherapy ( P < .001) were significantly correlated with overall survival from diagnosis. Conclusion: Stereotactic body radiotherapy is a safe and effective treatment for patients with locally advanced pancreatic cancer with no G3 toxicity or greater and could be a promising therapeutic option in multimodality treatment regimen.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
bkagyin应助陈苗采纳,获得10
19秒前
核桃发布了新的文献求助10
23秒前
Plum22完成签到 ,获得积分10
55秒前
自由觅松发布了新的文献求助20
1分钟前
1分钟前
核桃发布了新的文献求助10
1分钟前
深情安青应助科研通管家采纳,获得10
1分钟前
科研通AI2S应助科研通管家采纳,获得10
1分钟前
阳阳阳发布了新的文献求助10
1分钟前
阳阳阳完成签到,获得积分10
1分钟前
1分钟前
1分钟前
CATH完成签到 ,获得积分10
1分钟前
1分钟前
zhanghao发布了新的文献求助10
1分钟前
Hillson完成签到,获得积分10
2分钟前
糯糯完成签到 ,获得积分10
2分钟前
2分钟前
自由飞阳完成签到,获得积分10
2分钟前
小羡完成签到 ,获得积分10
2分钟前
滕皓轩完成签到 ,获得积分20
2分钟前
aDou完成签到 ,获得积分10
2分钟前
George完成签到,获得积分10
2分钟前
oscar发布了新的文献求助10
2分钟前
oscar完成签到,获得积分10
3分钟前
3分钟前
3分钟前
4分钟前
4分钟前
疯狂的自行车完成签到,获得积分20
5分钟前
Akim应助科研通管家采纳,获得10
5分钟前
我睡觉不会困12138完成签到 ,获得积分10
5分钟前
脑洞疼应助xiongdi521采纳,获得10
5分钟前
阿泽完成签到 ,获得积分10
6分钟前
疯狂的自行车关注了科研通微信公众号
6分钟前
kohu完成签到,获得积分10
6分钟前
6分钟前
kohu发布了新的文献求助10
6分钟前
6分钟前
正直的松鼠完成签到 ,获得积分10
6分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3990084
求助须知:如何正确求助?哪些是违规求助? 3532108
关于积分的说明 11256447
捐赠科研通 3271016
什么是DOI,文献DOI怎么找? 1805171
邀请新用户注册赠送积分活动 882270
科研通“疑难数据库(出版商)”最低求助积分说明 809228