[Change of bone mineral density in type 2 diabetes mellitus with nephropathy].

To investigate into the changes of bone mineral density(BMD) in Type 2 diabetes mellitus with nephropathy(DN) and without nephropathy(DM).BMD of lumbar vertebrae 1-4 and femur in 93 cases of Type 2 diabetes mellitus(41 cases of DN and 52 cases of DM) were measured with dual energy x-ray absorptiometry(DEXA) and were compared with age, sex, and BMI-matched normal control group.No significant differences were found in BMD of femoral total, neck, L1-L4 between DM and normal controls in females(P > 0.05). DM in men had higher BDM at L2, femoral total neck than normal controls(P < 0.05). BMD at femoral total, neck, in females and L1-L4 femoral total neck in men in DN group were lower than DM group, but had no statistical differences.The changes in BMD of above areas in DM were normal and higher because of different areas. BMD in DN had lower predisposition.