医学
麻醉
神经病理性疼痛
脊髓损伤
椎板切除术
痛觉超敏
脊髓
神经保护
痛觉过敏
伤害
内科学
精神科
受体
作者
Leila Farsi,Khashayar Afshari,Mansoor Keshavarz,Maryam Naghibzadeh,Faramarz Memari,Abbas Norouzi Javidan
出处
期刊:Behavioural Pharmacology
[Ovid Technologies (Wolters Kluwer)]
日期:2015-04-01
卷期号:26 (3): 315-320
被引量:7
标识
DOI:10.1097/fbp.0000000000000103
摘要
Spinal cord injury (SCI) has a number of severe and disabling consequences including chronic pain. Approximately 40% of patients experience neuropathic pain, which appears to be persistent. Previous studies have demonstrated the neuroprotective effects of magnesium sulfate (MgSO4). We aimed to investigate the effect of MgSO4 on neuropathic pains following SCI in male rats. Thirty-two adult male rats (weight 300–350 g) were used. After laminectomy, a complete SCI was induced by compression of the spinal cord for 1 min with an aneurysm clip. A single dose of 300 or 600 mg/kg MgSO4 was injected intraperitoneally. Tail-flick latency and acetone drop test scores were evaluated before surgery and once a week for 4 weeks after surgery. Rats in groups SCI+Mg300 and SCI+Mg600 showed significantly higher mean tail-flick latencies and lower mean scores in the acetone test compared with those in the SCI+veh group 4 weeks after surgery (P<0.05). These findings revealed that systemic single-dose administration of MgSO4 can attenuate thermal hyperalgesia and cold allodynia induced by SCI in rats.
科研通智能强力驱动
Strongly Powered by AbleSci AI