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ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTCatalytic Contributions from Remote Regions of Enzyme StructureJeeyeon Lee*‡ and Nina M. Goodey*§View Author Information‡ Department of Chemistry, 413 Wartik Laboratory, The Pennsylvania State University, University Park, Pennsylvania 16802, USA College of Pharmacy, Ajou University, San 5, Woncheon-dong, Yeongtong-Gu, Suwon, Korea 443-749§ Department of Chemistry and Biochemistry, Montclair State University, 1 Normal Avenue, Montclair, New Jersey 07043, USAE-mail: [email protected] and [email protected]. Phone: +82-31-219-3446 and (973) 655-3410.Cite this: Chem. Rev. 2011, 111, 12, 7595–7624Publication Date (Web):September 19, 2011Publication History Received8 February 2010Published online19 September 2011Published inissue 14 December 2011https://pubs.acs.org/doi/10.1021/cr100042nhttps://doi.org/10.1021/cr100042nreview-articleACS PublicationsCopyright © 2011 American Chemical SocietyRequest reuse permissionsArticle Views4022Altmetric-Citations82LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Catalysis,Conformation,Genetics,Peptides and proteins,Protein structure Get e-Alerts