Pharmacologic properties of 4-alkoxy-beta-(1-piperidyl) propiophenones.

Alkoxy substitution at the 4 position of the aromatic ring in β-(1-piperidyl)- propiophenone a. increases: (1) local anesthetic activity (2) spinal internuncial neuronal depressant action (3) depressant effects on the tremor of the canine tremor syndrome (4) central nervous system deliriant and convulsant effects b. abolishes cholinolytic activity. Local anesthetic potency, antitremor effectiveness and activity as a spinal internuncial neuronal depressant parallel the increase in side chain length reaching a maximum in substitutions varying from 4 to 7 carbons in length.