免疫学
免疫系统
促炎细胞因子
姜黄素
树突状细胞
系统性红斑狼疮
医学
生物
炎症
药理学
疾病
内科学
作者
Amir Abbas Momtazi‐Borojeni,Saeed Mohammadian Haftcheshmeh,Seyed‐Alireza Esmaeili,Thomas P. Johnston,Elham Abdollahi,Amirhossein Sahebkar
标识
DOI:10.1016/j.autrev.2017.11.016
摘要
Curcumin is a polyphenol natural product isolated from turmeric, interacting with different cellular and molecular targets and, consequently, showing a wide range of pharmacological effects. Recent preclinical and clinical trials have revealed immunomodulatory properties of curcumin that arise from its effects on immune cells and mediators involved in the immune response, such as various T-lymphocyte subsets and dendritic cells, as well as different inflammatory cytokines. Systemic lupus erythematosus (SLE) is an inflammatory, chronic autoimmune-mediated disease characterized by the presence of autoantibodies, deposition of immune complexes in various organs, recruitment of autoreactive and inflammatory T cells, and excessive levels of plasma proinflammatory cytokines. The function and numbers of dendritic cells and T cell subsets, such as T helper 1 (Th1), Th17, and regulatory T cells have been found to be significantly altered in SLE. In the present report, we reviewed the results of in vitro, experimental (pre-clinical), and clinical studies pertaining to the modulatory effects that curcumin produces on the function and numbers of dendritic cells and T cell subsets, as well as relevant cytokines that participate in SLE.
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