CD137
抗体
癌症免疫疗法
癌症
免疫疗法
免疫系统
癌细胞
癌症研究
免疫学
医学
内科学
作者
Dinh‐Toi Chu,Nguyen Duy Bac,Khanh Hoang Nguyen,Nguyen Le Bao Tien,Vo Van Thanh,Vu Thi Nga,Võ Trương Như Ngọc,Duong Thi Anh Dao,Le Ngoc Hoan,Nguyễn Phúc Hưng,Nguyễn Thị Trung Thu,Van Huy Pham,Lê Nguyên Vũ,Thuy Anh Vu Pham,Deepak Raj
摘要
The selective expression of CD137 on cells of the immune system (e.g., T and DC cells) and oncogenic cells in several types of cancer leads this molecule to be an attractive target to discover cancer immunotherapy. Therefore, specific antibodies against CD137 are being studied and developed aiming to activate and enhance anti-cancer immune responses as well as suppress oncogenic cells. Accumulating evidence suggests that anti-CD137 antibodies can be used separately to prevent tumor in some cases, while in other cases, these antibodies need to be co-administered with other antibodies or drugs/vaccines/regents for a better performance. Thus, in this work, we aim to update and discuss current knowledge about anti-cancer effects of anti-CD137 antibodies as mono- and combined-immunotherapies.
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