肠沙门氏菌
生物
微生物学
结肠炎
粘液
沙门氏菌
毒力
肠道菌群
肠杆菌科
细菌
大肠杆菌
免疫学
基因
遗传学
生态学
作者
Simone Herp,Sandrine Brugiroux,Debora Garzetti,Diana Ring,Lara Jochum,Markus Beutler,Claudia Eberl,Saib Hussain,Steffi Walter,Roman G. Gerlach,Hans‐Joachim Ruscheweyh,Daniel H. Huson,Mikael E. Sellin,Emma Slack,Buck Hanson,Alexander Loy,John F. Baines,Philipp Rausch,Marijana Basic,David Berry,Bärbel Stecher
标识
DOI:10.1016/j.chom.2019.03.004
摘要
The microbiota and the gastrointestinal mucus layer play a pivotal role in protection against non-typhoidal Salmonella enterica serovar Typhimurium (S. Tm) colitis. Here, we analyzed the course of Salmonella colitis in mice lacking a functional mucus layer in the gut. Unexpectedly, in contrast to mucus-proficient littermates, genetically deficient mice were protected against Salmonella-induced gut inflammation in the streptomycin colitis model. This correlated with microbiota alterations and enrichment of the bacterial phylum Deferribacteres. Using gnotobiotic mice associated with defined bacterial consortia, we causally linked Mucispirillum schaedleri, currently the sole known representative of Deferribacteres present in the mammalian microbiota, to host protection against S. Tm colitis. Inhibition by M. schaedleri involves interference with S. Tm invasion gene expression, partly by competing for anaerobic electron acceptors. In conclusion, this study establishes M. schaedleri, a core member of the murine gut microbiota, as a key antagonist of S. Tm virulence in the gut.
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