生物
转录组
RNA序列
基因
核糖核酸
哺乳期
候选基因
计算生物学
基因表达
遗传学
乳腺
癌症
乳腺癌
怀孕
作者
T Vijaya Kumar,Sanniyasi Bakyaraj,A. Singaravadivelan,T. Vasanthakumar,Ramalingam Suresh
出处
期刊:Genome
[Canadian Science Publishing]
日期:2019-07-01
卷期号:62 (7): 489-501
被引量:6
标识
DOI:10.1139/gen-2018-0144
摘要
A better understanding of the biology of lactation, both in terms of gene expression and the identification of candidate genes for the production of milk and its components, is made possible by recent advances in RNA seq technology. The purpose of this study was to understand the synthesis of milk components and the molecular pathways involved, as well as to identify candidate genes for milk production traits within whole mammary transcriptomic datasets. We performed a meta-analysis of publically available RNA seq transcriptome datasets of mammary tissue/milk somatic cells. In total, 11 562 genes were commonly identified from all RNA seq based mammary gland transcriptomes. Functional annotation of commonly expressed genes revealed the molecular processes that contribute to the synthesis of fats, proteins, and lactose in mammary secretory cells and the molecular pathways responsible for milk synthesis. In addition, we identified several candidate genes responsible for milk production traits and constructed a gene regulatory network for RNA seq data. In conclusion, this study provides a basic understanding of the lactation biology of cows at the gene expression level.
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