Effects of SNPs in HE-relevant genes on the development of hepatic encephalopathy in patients with liver cirrhosis

Hepatic encephalopathy (HE) is a neuropsychiatric syndrome that emerges in acute and chronic liver failure. Currently, HE is seen as a clinical manifestation of a low grade cerebral edema and cerebral oxidative stress which disturbs oscillatory networks and synaptic plasticity in brain. Importantly, HE is a negative prognostic risk factor in liver cirrhosis for higher mortality.