纳米笼
肝X受体
系统性红斑狼疮
癌症研究
材料科学
吞噬作用
医学
免疫学
生物
内科学
疾病
核受体
生物化学
转录因子
基因
催化作用
作者
Nan Xu,Jun Li,Yujie Gao,Nan Zhou,Qiuying Ma,Michael Wu,Yamin Zhang,Xiaoyan Sun,Jun Xie,Guanxin Shen,Ming Yang,Qiming Tu,Xiaowei Xu,Jintao Zhu,Juan Tao
出处
期刊:Biomaterials
[Elsevier]
日期:2019-03-01
卷期号:197: 380-392
被引量:27
标识
DOI:10.1016/j.biomaterials.2019.01.034
摘要
Systemic lupus erythematosus (SLE) constitutes an autoimmune disease characterized by the breakdown of tolerance to self-antigens, sustained production of pathogenic autoantibodies, and damage to multiple organs and tissues. Nanoparticle (NP)-based therapeutics have demonstrated efficacy in attenuating the progression of SLE. However, investigations of nano-drugs that address the crucial initiating factor in the pathogenesis of SLE; e.g., inefficient clearance of apoptotic cells by phagocytes and consequent accumulation of self-antigens, have seldom been reported. Here, an apoptotic cell-mimicking gold nanocage (AuNC)-based nano drug carrier capable of correcting the impaired clearance of apoptotic cells in SLE was rationally designed and generated by conjugating phosphatidylserine (PS) on the surface of liposome-coated AuNCs for liver X receptor (LXR) agonist T0901317 delivery. Notably, [email protected] could efficiently enhance apoptotic cell clearance by elevating the expression of Mer, one of the pivotal phagocytosis-associated receptors on macrophages, resulting in decreased production of anti-dsDNA autoantibodies, reduced inflammatory response, and alleviation of kidney damage in lupus model mice. Additionally, PS-lipos-AuNC could be tracked by photoacoustic imaging for nano drug carrier biodistribution. By addressing the crucial pathogenic factor of SLE, the NP-based delivery system in this study is envisioned to provide a promising strategy to treat this complex and challenging disease.
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