断奶
哺乳期
大脑发育
后代
脑功能
功能(生物学)
生物
神经科学
生理学
药物开发
脑组织
怀孕
内分泌学
药品
细胞生物学
药理学
遗传学
作者
Wenjie Zhang,Yueling Zhang,Yuanjia Zheng,Mingxuan Zheng,Nannan Sun,Xiaoying Yang,Yong Gao
出处
期刊:Current Protein & Peptide Science
[Bentham Science Publishers]
日期:2019-01-25
卷期号:20 (7): 705-712
被引量:4
标识
DOI:10.2174/1389203720666190125095819
摘要
Lactation is a critical phase for brain function development. New dietary experiences of mouse caused by weaning can regulate brain development and function, increase their response to food and environment, and eventually give rise to corresponding behavioral changes. Changes in weaning time induce the alteration of brain tissues morphology and molecular characteristics, glial cell activity and behaviors in the offspring. In addition, it is also sensitive to the intervention of environment and drugs during this period. That is to say, the study focused on brain development and function based on mouse weaning is critical to demonstrate the underlying pathogenesis of neuropsychiatric diseases and find new drug targets. This article mainly focuses on the developmental differentiation of the brain during lactation, especially during weaning in mice.
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