Efficient Diastereoselective Titanium(IV) Reductive Amination of Ketones

An efficient method for the diastereoselective synthesis of various secondary amines through a titanium(IV) isopropoxide-mediated reductive amination reaction of ketones is reported. Thus, a series of different ketones and (R)-Phenylethylamine were involved leading to the expected products in moderate to excellent yields and importantly in diastereoselectivities up to 100% in one case. Keywords: Titanium, Reductive amination, Ketones, Secondary amines, Imines, Diastereoselectivity