芯片上器官
个性化医疗
再生医学
计算机科学
微加工
药物开发
精密医学
医学
生物信息学
纳米技术
药品
生物
药理学
病理
微流控
制作
遗传学
干细胞
材料科学
替代医学
作者
Aleksander Skardal,Thomas Shupe,Anthony Atala
出处
期刊:Elsevier eBooks
[Elsevier]
日期:2018-08-17
卷期号:: 769-786
被引量:9
标识
DOI:10.1016/b978-0-12-809880-6.00044-8
摘要
In recent years, advances in tissue engineering and microfabrication technologies have enabled rapid growth in the areas of in vitro organoid development as well as "body-on-a-chip" platforms. These three-dimensional (3D) model systems often are able to mimic human physiology more accurately than traditional 2D cultures and animal models. In this review, we describe progress that has been made to generate organ-on-a-chip platforms and more complex, multiorganoid body-on-a-chip platforms and their applications. These systems have the potential to affect biomedical applications dramatically in the areas of drug development, drug and toxicology screening, disease modeling, and the emerging area of personalized precision medicine.
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