生物
细胞生物学
颗粒酶
穿孔素
免疫系统
颗粒酶B
胞吐
细胞
衰老
淋巴因子激活杀伤细胞
分泌物
白细胞介素21
NK-92
免疫学
T细胞
CD8型
生物化学
遗传学
作者
Fabrizio Antonangeli,Alessandra Zingoni,Alessandra Soriani,Angela Santoni
标识
DOI:10.1002/jlb.mr0718-299r
摘要
Abstract NK cells are lymphocytes of the innate immune system, which are able to deal promptly with stressed cells. Cellular senescence is a cell stress response leading to cell cycle arrest that plays a key role during tissue homeostasis and carcinogenesis. In this review, how senescent cells trigger an immune response and, in particular, the ability of NK cells to recognize and clear senescent cells are discussed. Special attention is given to the NK cell-mediated clearance of senescent tumor cells. NK cells kill senescent cells through a mechanism involving perforin- and granzyme-containing granule exocytosis, and produce IFN-γ following senescent cell interaction, leading to hypothesize that NK cell-mediated immune clearance of senescent cells not only relies on direct killing but also on cytokine production, that in turn can promote macrophage activation. These aspects, as well as the ability of the senescence-associated secretory phenotype and senescent cell-produced extracellular vesicles to modulate NK cell effector functions, are described.
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