Chemokine receptor CXCR3 in peripheral blood in rheumatoid arthritis patients: its relation to disease activity and joint destruction

医学 类风湿性关节炎 滑膜炎 血沉 内科学 CXCR3型 胃肠病学 炎症 趋化因子受体 趋化因子
作者
Amal Mohamad El‐Barbary,Salwa A. Essa,Hossam Abdelhafiz Zaytoun
出处
期刊:Egyptian Rheumatology and Rehabilitation [Springer Science+Business Media]
卷期号:40 (2): 75-80 被引量:3
标识
DOI:10.7123/01.err.0000426387.26867.b1
摘要

The aim of this study was to investigate the role of CXCR3 in rheumatoid arthritis (RA) and its relation to disease activity, synovitis, and joint destruction. This study included 30 RA patients and 20 healthy controls. Morning stiffness, disease activity for 28 joint indices score (DAS-28), and Modified Health Assessment Questionnaire scores were estimated. Levels of erythrocyte sedimentation rate, C-reactive protein, rheumatoid factor, hemoglobin, and CXCR3 in peripheral blood were also determined. Radiological assessment included determination of the Van der Heijde modification scores for hands and feet and MRI scores for wrists and metacarpophalangeal joints for detection of synovitis and bone defects. CXCR3 levels in peripheral blood were found to be increased in RA patients compared with controls (P<0.001) and in patients with moderate and high RA activity scores. CXCR3 levels in peripheral blood were positively correlated with DAS-28 levels, Van der Heijde modification scores, and MRI scores for wrists and metacarpophalangeal joints for detection of synovitis and bone erosion. This study demonstrates an important role of CXCR3 in the pathogenesis of chronic inflammation in RA and that CXCR3 blockade may offer a new strategy for reducing the severity and inflammatory reaction in RA patients.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
万能图书馆应助wusuowei采纳,获得10
刚刚
斯文败类应助xcc采纳,获得10
1秒前
kingtongx应助Lu采纳,获得10
1秒前
Jattck发布了新的文献求助30
2秒前
上官若男应助huayi采纳,获得10
3秒前
lalala发布了新的文献求助10
3秒前
Malmever发布了新的文献求助30
4秒前
ottsannn完成签到,获得积分10
4秒前
大个应助蓦然回首采纳,获得10
4秒前
Dou_Xiaowen发布了新的文献求助10
5秒前
5秒前
baobaobaozi完成签到,获得积分20
5秒前
jyy应助包子采纳,获得10
6秒前
CodeCraft应助Cc采纳,获得10
7秒前
7秒前
8秒前
10秒前
黑风小妖完成签到,获得积分10
10秒前
11秒前
11秒前
hi应助爱偷懒的猪采纳,获得10
13秒前
星星完成签到,获得积分20
14秒前
大模型应助无情白羊采纳,获得10
14秒前
快乐滑板发布了新的文献求助10
14秒前
14秒前
永毅完成签到 ,获得积分10
14秒前
言亦云应助顺利的雁采纳,获得30
15秒前
豆花发布了新的文献求助50
15秒前
15秒前
hhhhhhhhh完成签到,获得积分10
16秒前
guoguo发布了新的文献求助10
16秒前
16秒前
隐形曼青应助杨乙友采纳,获得10
17秒前
17秒前
18秒前
19秒前
雨齐完成签到,获得积分10
20秒前
22秒前
22秒前
24秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3969557
求助须知:如何正确求助?哪些是违规求助? 3514377
关于积分的说明 11173836
捐赠科研通 3249692
什么是DOI,文献DOI怎么找? 1794979
邀请新用户注册赠送积分活动 875537
科研通“疑难数据库(出版商)”最低求助积分说明 804836