Chemokine receptor CXCR3 in peripheral blood in rheumatoid arthritis patients: its relation to disease activity and joint destruction

医学 类风湿性关节炎 滑膜炎 血沉 内科学 CXCR3型 胃肠病学 炎症 趋化因子受体 趋化因子
作者
Amal Mohamad El‐Barbary,Salwa A. Essa,Hossam Abdelhafiz Zaytoun
出处
期刊:Egyptian Rheumatology and Rehabilitation [Springer Science+Business Media]
卷期号:40 (2): 75-80 被引量:3
标识
DOI:10.7123/01.err.0000426387.26867.b1
摘要

The aim of this study was to investigate the role of CXCR3 in rheumatoid arthritis (RA) and its relation to disease activity, synovitis, and joint destruction. This study included 30 RA patients and 20 healthy controls. Morning stiffness, disease activity for 28 joint indices score (DAS-28), and Modified Health Assessment Questionnaire scores were estimated. Levels of erythrocyte sedimentation rate, C-reactive protein, rheumatoid factor, hemoglobin, and CXCR3 in peripheral blood were also determined. Radiological assessment included determination of the Van der Heijde modification scores for hands and feet and MRI scores for wrists and metacarpophalangeal joints for detection of synovitis and bone defects. CXCR3 levels in peripheral blood were found to be increased in RA patients compared with controls (P<0.001) and in patients with moderate and high RA activity scores. CXCR3 levels in peripheral blood were positively correlated with DAS-28 levels, Van der Heijde modification scores, and MRI scores for wrists and metacarpophalangeal joints for detection of synovitis and bone erosion. This study demonstrates an important role of CXCR3 in the pathogenesis of chronic inflammation in RA and that CXCR3 blockade may offer a new strategy for reducing the severity and inflammatory reaction in RA patients.
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