Effect of nasal allergen challenge in allergic rhinitis on mitochondrial function of peripheral blood mononuclear cells

Allergic rhinitis is the most common of the atopic diseases, affecting up to 25% of the population worldwide. [1] Bousquet J. Schunemann H.J. Samolinski B. et al. Allergic Rhinitis and its Impact on Asthma (ARIA): achievements in 10 years and future needs. J Allergy Clin Immunol. 2012; 130: 1049-1062 Abstract Full Text Full Text PDF PubMed Scopus (443) Google Scholar Grass pollen sensitization has been recognized as a major cause of allergic rhinitis. On the pathophysiologic level, allergic rhinitis is an IgE-mediated inflammation of the nasal mucosa. Grass pollen allergy, commonly called hay fever, can also cause more general symptoms, such as as fatigue and unwellness as seen in flulike syndromes. This might be partly related to the activation of a systemic inflammatory pathway after the local nasal inflammatory response, but data from studies concerning the systemic effects of nasal mucosal allergen exposure are limited.