生物利用度
溃疡性结肠炎
吸收不良
食品科学
化学
营养物
溶解度
吸收(声学)
脂质代谢
维生素
新陈代谢
功能性食品
维生素C
内科学
生物化学
药理学
医学
材料科学
疾病
有机化学
复合材料
作者
Yiwen Guo,Tao Zhang,Ying Xu,Emad Karrar,Min‐Jie Cao,Xiaotian Sun,Ruijie Liu,Ming Chang,Xingguo Wang
标识
DOI:10.1021/acs.jafc.2c07437
摘要
Due to intestinal malabsorption and poor water solubility, vitamin D (VitD) deficiency in ulcerative colitis (UC) continues to increase. Medium- and long-chain triacylglycerols (MLCT), as novel lipids, have been widely applied in the field of functional food and medicine nutrition. Our previous studies showed that the difference in MLCT structure could affect VitD bioaccessibility in vitro. In this study, our results further indicate that, although identical in fatty acid composition, structured triacylglycerol (STG) had a higher VitD bioavailability (AUC = 15470.81 μg/L × h) and metabolism efficacy [s-25(OH)D, p < 0.05] than physical mixtures of triacylglycerol (PM), which further affect the amelioration efficiency in UC mice. Compared with PM, the damage of colonic tissues, intestinal barrier proteins, and inflammatory cytokines in STG showed better amelioration at the same dose of VitD. This study provides a comprehensive understanding of the mechanism of nutrients in different carriers and a solution for developing nutrients with high absorption efficiency.
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