Staphylococcus Aureus and Streptococcus Pyogenes Induce Psoriasis-Related Transcriptomes Augmented by IL-17A and TNF-α

Keratinocyte (KC) response to bacteria contributes to inflammatory skin diseases by induction of proinflammatory and antimicrobial responses. Recent studies show that atopic dermatitis lesions are dominated by Staphylococcus aureus (SA), whereas bacterial communities in psoriasis are diverse (Alekseyenko et al., 2013; Fyhrquist et al., 2019). Indeed, psoriasis is associated with multiple microbial species: one study reported that the combined relative abundance of Corynebacterium, Propionibacterium, Staphylococcus, and Streptococcus are increased in psoriatic epidermis (Alekseyenko et al., 2013), whereas another reported increased abundance of Corynebacterium simulans and Corynebacterium kroppenstedtii as well as Finegoldia and Neisseriaceae species (Fyhrquist et al., 2019).