核糖体生物发生
生物
核糖体
蛋白质生物合成
多细胞生物
细胞生物学
生物发生
翻译(生物学)
计算生物学
遗传学
基因
信使核糖核酸
核糖核酸
作者
Chunyang Ni,Michael Buszczak
出处
期刊:Development
[The Company of Biologists]
日期:2023-03-01
卷期号:150 (5)
被引量:13
摘要
ABSTRACT Although differential transcription drives the development of multicellular organisms, the ultimate readout of a protein-coding gene is ribosome-dependent mRNA translation. Ribosomes were once thought of as uniform molecular machines, but emerging evidence indicates that the complexity and diversity of ribosome biogenesis and function should be given a fresh look in the context of development. This Review begins with a discussion of different developmental disorders that have been linked with perturbations in ribosome production and function. We then highlight recent studies that reveal how different cells and tissues exhibit variable levels of ribosome production and protein synthesis, and how changes in protein synthesis capacity can influence specific cell fate decisions. We finish by touching upon ribosome heterogeneity in stress responses and development. These discussions highlight the importance of considering both ribosome levels and functional specialization in the context of development and disease.
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