ZIF-67 MOF derived Co-Based CeO2 electrochemical sensor for dopamine

In the field of biosensing and disease diagnosis, rapid and sensitive detection of dopamine (DA) is essential. In this work, Co3O4 with a porous structure was prepared by temperature-controlled calcination of the precursor template zeolite imidazole framework-67 (ZIF-67), and CeO2/Co3O4 composites with a porous framework structure were prepared by hydrothermal methods. The porous structure of the Co3O4 prevented the aggregation of the CeO2 nanoparticles and allowed them to be dispersed in a uniform manner on the surface. The CeO2 introduction led to changes in the specific surface area and pore size of the calcined Co3O4 material, and more active sites were exposed, allowing better binding with CeO2 thus achieving good catalytic performance and excellent synergistic properties. The CeO2 /Co3O4 modification on the surface of glassy carbon electrodes (GCE) showed good electrocatalytic activity, which was superior to that of pure Co3O4 and CeO2, as determined by electrochemical methods, thanks to. The results show that CeO2/Co3O4/GCE has a limit of detection (LOD) of 0.13 μM for DA (S/N = 3) and a linear range of 0.13 μM-60 μM, as well as good interference resistance and reproducibility. This work provides a new solution for excellent dopamine sensors in Co3O4 and CeO2 composites, which can be extended to other biosensing applications.