免疫突触
细胞生物学
细胞溶解
细胞
免疫疗法
生物
抑制性突触后电位
自然杀伤细胞
受体
免疫系统
免疫学
化学
T细胞
细胞毒性T细胞
神经科学
T细胞受体
体外
生物化学
遗传学
作者
Se‐Chan Oh,Seong-Eun Kim,In-Hwan Jang,Seok‐min Kim,Soo Yun Lee,Sun‐Young Lee,In‐Sun Chu,Suk Ran Yoon,Haiyoung Jung,Inpyo Choi,Junsang Doh,Tae‐Don Kim
标识
DOI:10.1038/s41590-022-01394-w
摘要
The formation of an immunological synapse (IS) is essential for natural killer (NK) cells to eliminate target cells. Despite an advanced understanding of the characteristics of the IS and its formation processes, the mechanisms that regulate its stability via the cytoskeleton are unclear. Here, we show that Nogo receptor 1 (NgR1) has an important function in modulating NK cell-mediated killing by destabilization of IS formation. NgR1 deficiency or blockade resulted in improved tumor control of NK cells by enhancing NK-to-target cell contact stability and regulating F-actin dynamics during IS formation. Patients with tumors expressing abundant NgR1 ligand had poor prognosis despite high levels of NK cell infiltration. Thus, our study identifies NgR1 as an immune checkpoint in IS formation and indicates a potential approach to improve the cytolytic function of NK cells in cancer immunotherapy.
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