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A combined predicting model for benign esophageal stenosis after simultaneous integrated boost in esophageal squamous cell carcinoma patients (GASTO1072)

列线图 医学 接收机工作特性 单变量 队列 内科学 食管鳞状细胞癌 肿瘤科 狭窄 放化疗 单变量分析 一致性 放射科 食管癌 食管切除术 多元分析 放射治疗 多元统计 癌症 统计 数学
作者
Weitong Liu,Chengbing Zeng,Siyan Wang,Yizhou Zhan,Ruihong Huang,Ting Luo,Guo-Bo Peng,Yanxuan Wu,Zihan Qiu,Derui Li,Fangcai Wu,Chuangzhen Chen
出处
期刊:Frontiers in Oncology [Frontiers Media]
卷期号:12 被引量:3
标识
DOI:10.3389/fonc.2022.1026305
摘要

We aimed to develop a combined predicting model for benign esophageal stenosis (BES) after simultaneous integrated boost (SIB) with concurrent chemotherapy in patients with esophageal squamous cell carcinoma (ESCC).This study included 65 patients with EC who underwent SIB with chemotherapy. Esophageal stenosis was evaluated using esophagograms and the severity of eating disorders. Risk factors were investigated using univariate and multivariate analyses. Radiomics features were extracted based on contrast-enhanced CT (CE-CT) before treatment. The least absolute shrinkage and selection operator (LASSO) regression analysis was used for feature selection and radiomics signature construction. The model's performance was evaluated using Harrell's concordance index and receiver operating characteristic curves.The patients were stratified into low- and high-risk groups according to BES after SIB. The area under the curves of the clinical model, Rad-score, and the combined model were 0.751, 0.820 and 0.864, respectively. In the validation cohort, the AUCs of these three models were 0.854, 0.883 and 0.917, respectively. The Hosmer-Lemeshow test showed that there was no deviation from model fitting for the training cohort (p=0.451) and validation cohort (p=0.481). The C-indexes of the nomogram were 0.864 and 0.958 for the training and validation cohort, respectively. The model combined with Rad-score and clinical factors achieved favorable prediction ability.Definitive chemoradiotherapy could alleviate tumor-inducing esophageal stenosis but result in benign stenosis. We constructed and tested a combined predicting model for benign esophageal stenosis after SIB. The nomogram incorporating both radiomics signature and clinical prognostic factors showed favorable predictive accuracy for BES in ESCC patients who received SIB with chemotherapy.Registered in www.Clinicaltrial.gov, ID: NCT01670409, August 12, 2012.
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