色氨酸
化学
组合化学
立体化学
氨基酸
生物化学
作者
Zhekai Xiao,Yazhou Li,Yuzhu Wu,Qiangqiang Chen,Shengbin Zhou,Vadim A. Soloshonok,Jiang Wang,Hong Liu
标识
DOI:10.1021/acs.joc.4c02406
摘要
We herein report the synthesis of substituted tryptophans using Ni(II) complexes of glycine and gramines. This reaction proceeds under operationally convenient and mild conditions, using inexpensive, nontoxic, and easily accessible reagents. The reactions feature high yields and virtually complete thermodynamically controlled diastereoselectivity, providing a convenient method for the synthesis of tailor-made tryptophans.
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