转录组
生物
胰腺
疾病
胰腺癌
间质细胞
生物信息学
计算生物学
癌症研究
癌症
病理
遗传学
基因
医学
内分泌学
基因表达
作者
Amelia Cephas,William L. Hwang,Anirban Maitra,Oren Parnas,Kathleen E. DelGiorno
出处
期刊:Gut
[BMJ]
日期:2023-03-30
卷期号:72 (6): 1211-1219
被引量:8
标识
DOI:10.1136/gutjnl-2022-329313
摘要
Recent advances in single-cell RNA sequencing and bioinformatics have drastically increased our ability to interrogate the cellular composition of traditionally difficult to study organs, such as the pancreas. With the advent of these technologies and approaches, the field has grown, in just a few years, from profiling pancreas disease states to identifying molecular mechanisms of therapy resistance in pancreatic ductal adenocarcinoma, a particularly deadly cancer. Single-cell transcriptomics and related spatial approaches have identified previously undescribed epithelial and stromal cell types and states, how these populations change with disease progression, and potential mechanisms of action which will serve as the basis for designing new therapeutic strategies. Here, we review the recent literature on how single-cell transcriptomic approaches have changed our understanding of pancreas biology and disease progression.
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