狼疮性肾炎
医学
肾小球疾病
急性肾损伤
免疫学
肾
趋化因子
肾脏疾病
肾小球肾炎
炎症
肾病
多囊肾病
糖尿病肾病
病理
疾病
内科学
糖尿病
内分泌学
作者
Yanlong Liu,Ke Xu,Yuhua Xiang,Ma Boyan,Hailong Li,Yuan Li,Shi Yue,S. Li,Yan Bai
标识
DOI:10.3389/fimmu.2023.1303076
摘要
The Monocyte chemoattractant protein-1 (MCP-1), also referred to as chemokine ligand 2 (CCL2), belongs to the extensive chemokine family and serves as a crucial mediator of innate immunity and tissue inflammation. It has a notable impact on inflammatory conditions affecting the kidneys. Upon binding to its receptor, MCP-1 can induce lymphocytes and NK cells’ homing, migration, activation, differentiation, and development while promoting monocytes’ and macrophages’ infiltration, thereby facilitating kidney disease-related inflammation. As a biomarker for kidney disease, MCP-1 has made notable advancements in primary kidney diseases such as crescentic glomerulonephritis, chronic glomerulonephritis, primary glomerulopathy, idiopathic proteinuria glomerulopathy, acute kidney injury; secondary kidney diseases like diabetic nephropathy and lupus nephritis; hereditary kidney diseases including autosomal dominant polycystic kidney disease and sickle cell kidney disease. MCP-1 not only predicts the occurrence, progression, prognosis of the disease but is also closely associated with the severity and stage of nephropathy. When renal tissue is stimulated or experiences significant damage, the expression of MCP-1 increases, demonstrating a direct correlation with the severity of renal injury.
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