Role of MCP-1 as an inflammatory biomarker in nephropathy

狼疮性肾炎 医学 肾小球疾病 急性肾损伤 免疫学 趋化因子 肾脏疾病 肾小球肾炎 炎症 肾病 多囊肾病 糖尿病肾病 病理 疾病 内科学 糖尿病 内分泌学
作者
Yanlong Liu,Ke Xu,Yuhua Xiang,Ma Boyan,Hailong Li,Yuan Li,Shi Yue,S. Li,Yan Bai
出处
期刊:Frontiers in Immunology [Frontiers Media SA]
卷期号:14 被引量:8
标识
DOI:10.3389/fimmu.2023.1303076
摘要

The Monocyte chemoattractant protein-1 (MCP-1), also referred to as chemokine ligand 2 (CCL2), belongs to the extensive chemokine family and serves as a crucial mediator of innate immunity and tissue inflammation. It has a notable impact on inflammatory conditions affecting the kidneys. Upon binding to its receptor, MCP-1 can induce lymphocytes and NK cells’ homing, migration, activation, differentiation, and development while promoting monocytes’ and macrophages’ infiltration, thereby facilitating kidney disease-related inflammation. As a biomarker for kidney disease, MCP-1 has made notable advancements in primary kidney diseases such as crescentic glomerulonephritis, chronic glomerulonephritis, primary glomerulopathy, idiopathic proteinuria glomerulopathy, acute kidney injury; secondary kidney diseases like diabetic nephropathy and lupus nephritis; hereditary kidney diseases including autosomal dominant polycystic kidney disease and sickle cell kidney disease. MCP-1 not only predicts the occurrence, progression, prognosis of the disease but is also closely associated with the severity and stage of nephropathy. When renal tissue is stimulated or experiences significant damage, the expression of MCP-1 increases, demonstrating a direct correlation with the severity of renal injury.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
科目三应助xzy采纳,获得10
1秒前
加菲丰丰应助xzy采纳,获得20
1秒前
1秒前
科研的师弟应助Xander采纳,获得30
1秒前
Alicia发布了新的文献求助10
2秒前
骑猪看日落完成签到,获得积分10
2秒前
汉堡包应助科研通管家采纳,获得10
2秒前
不配.应助科研通管家采纳,获得20
2秒前
科目三应助科研通管家采纳,获得10
2秒前
852应助科研通管家采纳,获得10
2秒前
科研通AI2S应助科研通管家采纳,获得10
2秒前
天天快乐应助科研通管家采纳,获得10
2秒前
上官若男应助科研通管家采纳,获得10
2秒前
思源应助科研通管家采纳,获得10
3秒前
bkagyin应助科研通管家采纳,获得10
3秒前
华仔应助科研通管家采纳,获得20
3秒前
上官若男应助科研通管家采纳,获得30
3秒前
不配.应助科研通管家采纳,获得20
3秒前
拨云见日发布了新的文献求助10
3秒前
小星星应助科研通管家采纳,获得10
3秒前
小墨应助科研通管家采纳,获得10
3秒前
加菲丰丰应助科研通管家采纳,获得10
3秒前
顾矜应助科研通管家采纳,获得10
3秒前
3秒前
3秒前
South朝484发布了新的文献求助10
3秒前
神勇的秋完成签到,获得积分10
4秒前
4秒前
Mycee完成签到,获得积分10
4秒前
4秒前
A9W01U完成签到,获得积分10
5秒前
6秒前
Owen应助w934420513采纳,获得10
6秒前
呼哒呼哒完成签到,获得积分10
6秒前
Joe完成签到,获得积分20
6秒前
孤独如花完成签到,获得积分10
7秒前
Chauncy完成签到,获得积分20
7秒前
pzh完成签到 ,获得积分10
7秒前
柠檬茶156发布了新的文献求助10
7秒前
高分求助中
Evolution 10000
Sustainability in Tides Chemistry 2800
юрские динозавры восточного забайкалья 800
English Wealden Fossils 700
An Introduction to Geographical and Urban Economics: A Spiky World Book by Charles van Marrewijk, Harry Garretsen, and Steven Brakman 500
Diagnostic immunohistochemistry : theranostic and genomic applications 6th Edition 500
Chen Hansheng: China’s Last Romantic Revolutionary 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3151396
求助须知:如何正确求助?哪些是违规求助? 2802862
关于积分的说明 7850843
捐赠科研通 2460290
什么是DOI,文献DOI怎么找? 1309701
科研通“疑难数据库(出版商)”最低求助积分说明 628997
版权声明 601760