刺
虾青素
化学
干扰素基因刺激剂
先天免疫系统
药理学
免疫系统
免疫学
生物
生物化学
工程类
类胡萝卜素
航空航天工程
作者
Qizhao Li,Mutian Jia,Hui Song,Jun Peng,Wei Zhao,Weifang Zhang
出处
期刊:Journal of Immunology
[The American Association of Immunologists]
日期:2024-02-23
卷期号:212 (7): 1188-1195
标识
DOI:10.4049/jimmunol.2300306
摘要
Abstract STING-mediated DNA sensing pathway plays a crucial role in the innate antiviral immune responses. Clarifying its regulatory mechanism and searching STING agonists has potential clinical implications. Although multiple STING agonists have been developed to target cancer, there are few for the treatment of infectious diseases. Astaxanthin, a natural and powerful antioxidant, serves many biological functions and as a potential candidate drug for many diseases. However, how astaxanthin combats viruses and whether astaxanthin regulates the cyclic GMP-AMP synthase–STING pathway remains unclear. In this study, we showed that astaxanthin markedly inhibited HSV-1–induced lipid peroxidation and inflammatory responses and enhanced the induction of type I IFN in C57BL/6J mice and mouse primary peritoneal macrophages. Mechanistically, astaxanthin inhibited HSV-1 infection and oxidative stress-induced STING carbonylation and consequently promoted STING translocation to the Golgi apparatus and oligomerization, which activated STING-dependent host defenses. Thus, our study reveals that astaxanthin displays a strong antiviral activity by targeting STING, suggesting that astaxanthin might be a promising STING agonist and a therapeutic target for viral infectious diseases.
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