醛脱氢酶
酶
生物化学
小分子
醛
计算生物学
化学
组合化学
生物
药理学
催化作用
作者
Biswajit Kundu,Malliga R. Iyer
标识
DOI:10.1080/13543776.2023.2287515
摘要
Introduction Physiological and pathophysiological effects arising from detoxification of aldehydes in humans implicate the enzyme aldehyde dehydrogenase (ALDH) gene family comprising of 19 isoforms. The main function of this enzyme family is to metabolize reactive aldehydes to carboxylic acids. Dysregulation of ALDH activity has been associated with various diseases. Extensive research has since gone into studying ALHD isozymes, their structural biology and developing small-molecule inhibitors. Novel chemical strategies to enhance the selectivity of ALDH inhibitors have now appeared.
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