Pluripotent stem cell-based cardiac regenerative therapy for heart failure

诱导多能干细胞 移植 心内膜 心力衰竭 再生医学 细胞疗法 干细胞 医学 心脏病学 细胞生物学 内科学 生物 胚胎干细胞 生物化学 基因
作者
Y Soma,Hidenori Tani,Yuika Morita-Umei,Yoshikazu Kishino,Keiichi Fukuda,Shugo Tohyama
出处
期刊:Journal of Molecular and Cellular Cardiology [Elsevier]
卷期号:187: 90-100 被引量:3
标识
DOI:10.1016/j.yjmcc.2023.12.001
摘要

Abstract

Cardiac regenerative therapy using human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) is expected to become an alternative to heart transplantation for severe heart failure. It is now possible to produce large numbers of human pluripotent stem cells (hPSCs) and eliminate non-cardiomyocytes, including residual undifferentiated hPSCs, which can cause teratoma formation after transplantation. There are two main strategies for transplanting hPSC-CMs: injection of hPSC-CMs into the myocardium from the epicardial side, and implantation of hPSC-CM patches or engineered heart tissues onto the epicardium. Transplantation of hPSC-CMs into the myocardium of large animals in a myocardial infarction model improved cardiac function. The engrafted hPSC-CMs matured, and microvessels derived from the host entered the graft abundantly. Furthermore, as less invasive methods using catheters, injection into the coronary artery and injection into the myocardium from the endocardium side have recently been investigated. Since transplantation of hPSC-CMs alone has a low engraftment rate, various methods such as transplantation with the extracellular matrix or non-cardiomyocytes and aggregation of hPSC-CMs have been developed. Post-transplant arrhythmias, imaging of engrafted hPSC-CMs, and immune rejection are the remaining major issues, and research is being conducted to address them. The clinical application of cardiac regenerative therapy using hPSC-CMs has just begun and is expected to spread widely if its safety and efficacy are proven in the near future.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
天天快乐应助牧友桃采纳,获得10
刚刚
魔幻灯泡完成签到,获得积分10
1秒前
薰硝壤应助科研顺荔采纳,获得10
2秒前
3秒前
过时的画板完成签到 ,获得积分10
3秒前
白水完成签到,获得积分10
4秒前
胡茶茶发布了新的文献求助10
5秒前
ysyzxs完成签到,获得积分10
5秒前
cessy完成签到,获得积分10
6秒前
7秒前
10秒前
无私文博完成签到,获得积分10
10秒前
YUE发布了新的文献求助20
11秒前
爆米花应助张朝程采纳,获得10
13秒前
超级柜子发布了新的文献求助10
14秒前
zyt发布了新的文献求助30
15秒前
15秒前
16秒前
nan发布了新的文献求助10
16秒前
17秒前
18秒前
所所应助胡茶茶采纳,获得10
18秒前
Yuxuan发布了新的文献求助30
20秒前
Akim应助ber采纳,获得10
21秒前
21秒前
qqq发布了新的文献求助10
23秒前
24秒前
大鱼发布了新的文献求助10
24秒前
西柚发布了新的文献求助10
25秒前
26秒前
28秒前
共享精神应助给桃子采纳,获得10
29秒前
zhanks完成签到,获得积分10
29秒前
30秒前
30秒前
31秒前
干净元槐发布了新的文献求助10
31秒前
LEMONS发布了新的文献求助10
32秒前
燕儿应助Diane01采纳,获得10
33秒前
最好的发布了新的文献求助10
36秒前
高分求助中
Sustainability in Tides Chemistry 1500
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
CLSI EP47 Evaluation of Reagent Carryover Effects on Test Results, 1st Edition 800
Threaded Harmony: A Sustainable Approach to Fashion 799
Livre et militantisme : La Cité éditeur 1958-1967 500
Retention of title in secured transactions law from a creditor's perspective: A comparative analysis of selected (non-)functional approaches 500
"Sixth plenary session of the Eighth Central Committee of the Communist Party of China" 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3055401
求助须知:如何正确求助?哪些是违规求助? 2712227
关于积分的说明 7430195
捐赠科研通 2357037
什么是DOI,文献DOI怎么找? 1248528
科研通“疑难数据库(出版商)”最低求助积分说明 606737
版权声明 596093