自愈水凝胶
光动力疗法
光敏剂
抗生素
细菌
伤口愈合
抗菌活性
抗生素治疗
医学
微生物学
化学
外科
生物
遗传学
有机化学
作者
Shunying Liu,Yanhai Feng,Tan Yang,Jinyi Chen,Tao Yang,Xiaoyu Wang,Lingfei Li,Fangjie Wang,Huaping Liang,Julia‐Li Zhong,Chao Qi,Lei Xia
摘要
Abstract Bacterial wound infection has emerged as a pivotal threat to human health worldwide, and the situation has worsened owing to the gradual increase in antibiotic‐resistant bacteria caused by the improper use of antibiotics. To reduce the use of antibiotics and avoid the increase in antibiotic‐resistant bacteria, researchers are increasingly paying attention to photodynamic therapy, which uses light to produce reactive oxygen species to kill bacteria. Treating bacteria‐infected wounds by photodynamic therapy requires fixing the photosensitizer (PS) at the wound site and maintaining a certain level of wound humidity. Hydrogels are materials with a high water content and are well suited for fixing PSs at wound sites for antibacterial photodynamic therapy. Therefore, hydrogels are often loaded with PSs for treating bacteria‐infected wounds via antibacterial photodynamic therapy. In this review, we systematically summarised the antibacterial mechanisms and applications of PS‐loaded hydrogels for treating bacteria‐infected wounds via photodynamic therapy. In addition, the recent studies and the research status progresses of novel antibacterial hydrogels are discussed. Finally, the challenges and future prospects of PS‐loaded hydrogels are reviewed.
科研通智能强力驱动
Strongly Powered by AbleSci AI