烷基
卤化物
芳基
化学
芳基
药物化学
光化学
有机化学
作者
Jie Xu,Yun Lan,Bin Liu
标识
DOI:10.1021/acs.joc.3c02320
摘要
We disclose herein a light-induced Hantzsch ester-initiated aryl and alkyl radical generation protocol from aryl halides (Br and Cl) and alkyl iodides. This method provides access to a wide range of benzo-fused heterocycles and C(sp3)–C(sp3) coupling products. The reductive detosylation reaction has also been demonstrated using the same reaction conditions. Initial mechanism studies provide evidence of the formation of an alkyl radical.
科研通智能强力驱动
Strongly Powered by AbleSci AI