生物
精密医学
癌症
生物标志物发现
肿瘤微环境
计算生物学
癌症医学
癌症生物标志物
个性化医疗
癌症治疗
生物信息学
肿瘤科
内科学
医学
遗传学
蛋白质组学
基因
生物化学
作者
Antonio Passaro,Maise Al Bakir,Emily G. Hamilton,Maximilian Diehn,Fabrice André,Sinchita Roy‐Chowdhuri,Giannis Mountzios,Ignacio I. Wistuba,Charles Swanton,Solange Peters
出处
期刊:Cell
[Elsevier]
日期:2024-03-01
卷期号:187 (7): 1617-1635
被引量:17
标识
DOI:10.1016/j.cell.2024.02.041
摘要
Summary
The integration of cancer biomarkers into oncology has revolutionized cancer treatment, yielding remarkable advancements in cancer therapeutics and the prognosis of cancer patients. The development of personalized medicine represents a turning point and a new paradigm in cancer management, as biomarkers enable oncologists to tailor treatments based on the unique molecular profile of each patient's tumor. In this review, we discuss the scientific milestones of cancer biomarkers and explore future possibilities to improve the management of patients with solid tumors. This progress is primarily attributed to the biological characterization of cancers, advancements in testing methodologies, elucidation of the immune microenvironment, and the ability to profile circulating tumor fractions. Integrating these insights promises to continually advance the precision oncology field, fostering better patient outcomes.
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