生物
甲基转移酶
癌症
甲基化
核糖核酸
癌症研究
疾病
生物信息学
DNA甲基化
计算生物学
内科学
遗传学
医学
基因
基因表达
作者
Jing Hu,Shizhi Wang,Xiuting Li
出处
期刊:Epigenomics
[Future Medicine]
日期:2024-04-19
标识
DOI:10.2217/epi-2024-0002
摘要
Cervical cancer (CC) remains one of the most common malignancies among women worldwide, posing a serious threat to women's health. N6-methyladenosine (m 6 A) modification, as the most abundant type of RNA methylation modification, and has been found to play a crucial role in various cancers. Current research suggests a close association between RNA m 6 A modification and the occurrence and progression of CC, encompassing disruptions in m 6 A levels and its regulatory machinery. This review summarizes the current status of m 6 A modification research in CC, explores the mechanisms underlying m 6 A levels and regulators (methyltransferases, demethylases, reader proteins) in CC and examines the application of small-molecule inhibitors of m 6 A regulators in disease treatment. The findings provide new insights into the future treatment of CC.
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